Two sample MR report
IRF5_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.4018604 | 1.3986490 | 0.8218840 |
| Weighted median | 3 | 0.0434670 | 0.0209229 | 0.0377569 |
| Inverse variance weighted | 3 | 0.0395565 | 0.0165038 | 0.0165384 |
| Simple mode | 3 | 0.0464099 | 0.0246527 | 0.2004698 |
| Weighted mode | 3 | 0.0463291 | 0.0217855 | 0.1673141 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2638770 | 1 | 0.6074690 |
| Inverse variance weighted | 0.3309873 | 2 | 0.8474753 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1527424 | 0.5896105 | 0.838627 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.87e-05 | 0 | TRUE | 0.612406 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
